Mouse unc-51-like kinase 1 (C. elegans) ELISA Kit | ULK1 elisa kit
Mouse Serine/threonine-protein kinase ULK1, ULK1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
ULK1: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. Interacts with GABARAP and GABARAPL2. Interacts (via C- terminus) with ATG13/KIAA0652. Part of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR; the association depends on nutrient conditions and is reduced during starvation. Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Protein type: Autophagy; Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; ULK family
Cellular Component: neuron projection; cytoplasmic vesicle membrane; cell soma; membrane; pre-autophagosomal structure membrane; cytoplasm; autophagic vacuole; cytosol
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; protein complex binding; kinase activity; Hsp90 protein binding; protein kinase binding; ATP binding; Rab GTPase binding; protein kinase activity
Biological Process: axon extension; protein amino acid autophosphorylation; neurite regeneration; negative regulation of collateral sprouting; signal transduction; cerebellar granule cell differentiation; protein amino acid phosphorylation; radial glia guided migration of granule cell; response to starvation; peptidyl-serine phosphorylation; cellular response to nutrient levels; protein localization; axonogenesis; regulation of gene expression; receptor internalization; Ras protein signal transduction; autophagy; regulation of autophagy; regulation of nerve growth factor receptor signaling pathway; positive regulation of macroautophagy; phosphorylation; neurite development; positive regulation of autophagy; autophagic vacuole formation
Research Articles on ULK1
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Product Notes
The Mouse ULK1 ulk1 (Catalog #AAA9326629) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9326629 ELISA Kit recognizes Mouse ULK1. It is sometimes possible for the material contained within the vial of "unc-51-like kinase 1 (C. elegans), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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