Mouse phosphatidylinositol glycan anchor biosynthesis, class A ELISA Kit | PIGA elisa kit
Mouse Phosphatidylinositol N-acetylglucosaminyltransferase subunit A, PIGA ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PIGA: Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis. Defects in PIGA are the cause of paroxysmal nocturnal hemoglobinuria (PNH). PNH is a disorder characterized by hemolytic anemia with hemoglobinuria, thromboses in large vessels, and a deficiency in hematopoiesis. Clinical manifestation of red blood cell breakdown with release of hemoglobin into the urine is manifested most prominently by dark-colored urine in the morning. Defects in PIGA are the cause of multiple congenital anomalies-hypotonia-seizures syndrome type 2 (MCAHS2). An X-linked recessive developmental disorder characterized by dysmorphic features, neonatal hypotonia, myoclonic seizures, and variable congenital anomalies involving the central nervous, cardiac, and urinary systems. Most affected individuals die in infancy. Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Transferase; Membrane protein, integral; EC 2.4.1.198
Cellular Component: endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; membrane; endoplasmic reticulum; integral to membrane
Molecular Function: transferase activity; transferase activity, transferring glycosyl groups
Biological Process: GPI anchor biosynthetic process; biosynthetic process
Research Articles on PIGA
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Product Notes
The Mouse PIGA piga (Catalog #AAA9325847) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325847 ELISA Kit recognizes Mouse PIGA. It is sometimes possible for the material contained within the vial of "phosphatidylinositol glycan anchor biosynthesis, class A, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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