Human ubiquitin specific peptidase 1 ELISA Kit | USP1 elisa kit
Human Ubiquitin carboxyl-terminal hydrolase 1, USP1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
USP1: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity. Interacts with FANCD2 and PCNA. Interacts with WDR48. Down-regulated following DNA damage. Belongs to the peptidase C19 family.
Protein type: EC 3.4.19.12; Ubiquitin-specific protease; Ubiquitin conjugating system; Protease
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity
Biological Process: regulation of DNA repair; proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; DNA repair; skeletal development; response to UV
Research Articles on USP1
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Product Notes
The Human USP1 usp1 (Catalog #AAA9325244) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325244 ELISA Kit recognizes Human USP1. It is sometimes possible for the material contained within the vial of "ubiquitin specific peptidase 1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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