Rat PRKC, apoptosis, WT1, regulator ELISA Kit | PAWR elisa kit
Rat PRKC apoptosis WT1 regulator protein, PAWR ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
expression is induced by apoptosis effector ionomycin; may play a role in apoptosis [RGD, Feb 2006]
Uniprot Description
PAR-4: a proapoptotic protein that drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappaB transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Protein type: Apoptosis
Cellular Component: cytoplasm; plasma membrane; actin filament; nucleus; actin cytoskeleton
Molecular Function: protein binding; leucine zipper domain binding; enzyme binding; actin binding
Biological Process: actin filament bundle formation; negative regulation of T cell proliferation; interleukin-2 biosynthetic process; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; negative regulation of T cell receptor signaling pathway; negative regulation of B cell proliferation; positive regulation of amyloid precursor protein biosynthetic process
Research Articles on PAWR
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Product Notes
The Rat PAWR pawr (Catalog #AAA9325122) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9325122 ELISA Kit recognizes Rat PAWR. It is sometimes possible for the material contained within the vial of "PRKC, apoptosis, WT1, regulator, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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