Human ring finger protein 216 ELISA Kit | RNF216 elisa kit
Human E3 ubiquitin-protein ligase RNF216, RNF216 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]
Uniprot Description
TRIAD3: Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase; EC 6.3.2.-; Ligase
Chromosomal Location of Human Ortholog: 7p22.1
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; zinc ion binding; ligase activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; viral reproduction; apoptosis; regulation of interferon-beta production; regulation of defense response to virus by host
Disease: Gordon Holmes Syndrome
Research Articles on RNF216
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Product Notes
The Human RNF216 rnf216 (Catalog #AAA9324504) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324504 ELISA Kit recognizes Human RNF216. It is sometimes possible for the material contained within the vial of "ring finger protein 216, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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