Human Ras association (RalGDS/AF-6) domain family member 5 ELISA Kit | RASSF5 elisa kit
Human Ras association domain-containing protein 5, RASSF5 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
RASSF5: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS1 and KRAS induced apoptosis. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytoskeletal; Tumor suppressor; Autophagy; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: microtubule; cytoplasm; nucleus
Molecular Function: protein binding; metal ion binding
Biological Process: negative regulation of cell proliferation; positive regulation of protein ubiquitination; apoptosis
Research Articles on RASSF5
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Product Notes
The Human RASSF5 rassf5 (Catalog #AAA9324115) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324115 ELISA Kit recognizes Human RASSF5. It is sometimes possible for the material contained within the vial of "Ras association (RalGDS/AF-6) domain family member 5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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