Human solute carrier family 18 (vesicular monoamine) , member 2 ELISA Kit | SLC18A2 elisa kit
Human Synaptic vesicular amine transporter, SLC18A2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]
Uniprot Description
SLC18A2: Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis. Belongs to the major facilitator superfamily. Vesicular transporter family.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter
Chromosomal Location of Human Ortholog: 10q25
Cellular Component: synaptic vesicle; synaptic vesicle membrane; cell soma; membrane; integral to plasma membrane; plasma membrane; terminal button
Molecular Function: serotonin transmembrane transporter activity; enzyme binding; amine transmembrane transporter activity; heat shock protein binding; monoamine transmembrane transporter activity; drug binding
Biological Process: dopamine transport; neurotransmitter secretion; amine transport; death; response to amphetamine; monoamine transport; locomotory behavior; response to herbicide; glucose homeostasis; endocytic recycling; sequestering of neurotransmitter; response to cocaine; post-embryonic development; response to starvation; synaptic transmission; insulin secretion; response to zinc ion; serotonin transport; transmembrane transport; negative regulation of neurotransmitter transport; aging; response to corticosterone stimulus
Research Articles on SLC18A2
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Product Notes
The Human SLC18A2 slc18a2 (Catalog #AAA9324108) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324108 ELISA Kit recognizes Human SLC18A2. It is sometimes possible for the material contained within the vial of "solute carrier family 18 (vesicular monoamine) , member 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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