Human pellino homolog 3 (Drosophila) ELISA Kit | PELI3 elisa kit
Human Protein pellino homolog 3, PELI3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Uniprot Description
PELI3: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. Belongs to the pellino family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.19; EC 6.3.2.-; Adaptor/scaffold; Ligase; Ubiquitin ligase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: cytosol
Molecular Function: ubiquitin-protein ligase activity; ligase activity
Biological Process: negative regulation of Toll signaling pathway; negative regulation of protein ubiquitination; defense response to Gram-negative bacterium; negative regulation of interferon type I production; Toll signaling pathway
Research Articles on PELI3
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Product Notes
The Human PELI3 peli3 (Catalog #AAA9324018) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324018 ELISA Kit recognizes Human PELI3. It is sometimes possible for the material contained within the vial of "pellino homolog 3 (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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