Western Blot (WB)
(Western blot analysis of Pellino-3 expression in A549 (A), HeLa (B) whole cell lysates.)
Rabbit anti-Human Pellino-3 Polyclonal Antibody | anti-PELI3 antibody
Anti-Pellino-3 Antibody
Western Blot (WB)
(Western blot analysis of Pellino-3 expression in A549 (A), HeLa (B) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of Pellino-3 expression in A549 (A), HeLa (B) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a scaffold protein and an intermediate signaling protein in the innate immune response pathway. The encoded protein helps transmit the immune response signal from Toll-like receptors to IRAK1/TRAF6 complexes. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Uniprot Description
Function: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1. Not required for NF-kappa-B activation. Ref.1 Ref.6
Pathway: Protein modification; protein ubiquitination.
Subunit structure: Interacts with TRAF6, IRAK1, MAP3K14 and MAP3K7. Ref.1
Tissue specificity: Highly expressed in brain, heart and testis, and at lower level in kidney, liver, lung, placenta, small intestine, spleen and stomach. Isoform 1 is not expressed in lung. Ref.1
Post-translational modification: Phosphorylated by IRAK1 enhancing its E3 ligase activity. Ref.5
Sequence similarities: Belongs to the pellino family.
Sequence caution: The sequence BAC11499.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on PELI3
Similar Products
Product Notes
The PELI3 peli3 (Catalog #AAA8307646) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Pellino-3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Pellino-3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the PELI3 peli3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Pellino-3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
