Human NLR family, pyrin domain containing 2 ELISA Kit | NLRP2 elisa kit

Human NACHT, LRR and PYD domains-containing protein 2, NLRP2 ELISA Kit

Cat. Num. AAA9323815

• Gene Names: NLRP2; NBS1; PAN1; NALP2; PYPAF2; CLR19.9
• Reactivity: Human
• Synonyms: NLR family; pyrin domain containing 2; Human NACHT; LRR and PYD domains-containing protein 2; NLRP2 ELISA Kit; LRR and PYD domains-containing protein 2 (NLRP2) ELISA kit; CLR19.9; FLJ20510; NALP2; NBS1; PAN1; PYPAF2; NACHT; LRR and PYD containing protein 2; leucine rich repeat and PYD containing 2; PYRIN-Containing APAF1-like; nucleotide-binding oligomerization d; NLRP2 elisa kit

• Reactivity: Human
• Specificity: No significant cross-reactivity or interference between this analyte and analogues is observed.

• Assay Type: Quantitative Sandwich
• Detection Range: 3.12 ng/ml - 100 ng/ml
• Sensitivity: 1.0 ng/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for NLRP2 elisa kit

Background: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of NLRP2 (hereafter termed "analyte") in undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 291463275
• NCBI GeneID: 55655
• NCBI Accession #: NP_001167552.1
• NCBI GenBank Nucleotide #: NM_001174081.1
• UniProt Accession #: Q9NX02; Q53FL5; Q59G09; Q8IXT0; Q9BVN5; Q9H6G6; Q9HAV9; Q9NWK3; B4DZL7; I3L0G4
• Molecular Weight: 120,515 Da
• NCBI Official Full Name: NACHT, LRR and PYD domains-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: NLR family, pyrin domain containing 2
• NCBI Official Symbol: NLRP2
• NCBI Official Synonym Symbols: NBS1; PAN1; NALP2; PYPAF2; CLR19.9
• NCBI Protein Information: NACHT, LRR and PYD domains-containing protein 2; nucleotide-binding site protein 1; PYRIN-containing APAF1-like protein 2; NACHT, LRR and PYD containing protein 2; NACHT, leucine rich repeat and PYD containing 2; PYRIN domain and NACHT domain-containing protein 1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2
• UniProt Protein Name: NACHT, LRR and PYD domains-containing protein 2
• Protein Family: NACHT, LRR and PYD domains-containing protein
• UniProt Gene Name: NLRP2
• UniProt Synonym Gene Names: NALP2; NBS1; PAN1; PYPAF2
• UniProt Entry Name: NALP2_HUMAN

NCBI Description

NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008]

Uniprot Description

NLRP2: Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.42

Cellular Component: cytoplasm

Molecular Function: protein binding; ATP binding; Pyrin domain binding

Biological Process: positive regulation of caspase activity; positive regulation of interleukin-1 beta secretion