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Mouse thyroid stimulating hormone receptor ELISA Kit | TSHR elisa kit

Mouse Thyrotropin receptor, TSHR ELISA Kit

Gene Names
Tshr; hyt; pet; AI481368; hypothroid
Reactivity
Mouse
Synonyms
thyroid stimulating hormone receptor; Mouse Thyrotropin receptor; TSHR ELISA Kit; Mouse Thyrotropin receptor (TSHR) ELISA kit; CHNG1; LGR3; MGC75129; hTSHR-I; seven transmembrane helix receptor; isoform 2; thyrotropin receptor; thyrotropin receptor-I; TSHR elisa kit
Ordering
For Research Use Only!
Reactivity
Mouse
Preparation and Storage
Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
86,583 Da
NCBI Official Full Name
thyrotropin receptor isoform 1
NCBI Official Synonym Full Names
thyroid stimulating hormone receptor
NCBI Official Symbol
Tshr
NCBI Official Synonym Symbols
hyt; pet; AI481368; hypothroid
NCBI Protein Information
thyrotropin receptor; TSH-R; thyroid-stimulating hormone receptor
UniProt Protein Name
Thyrotropin receptor
Protein Family
UniProt Gene Name
Tshr
UniProt Synonym Gene Names
TSH-R
UniProt Entry Name
TSHR_MOUSE

Uniprot Description

TSHR: Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). Defects in TSHR are found in patients affected by hyperthyroidism with different etiologies. Somatic, constitutively activating TSHR mutations and/or constitutively activating G(s)alpha mutations have been identified in toxic thyroid nodules (TTNs) that are the predominant cause of hyperthyroidism in iodine deficient areas. These mutations lead to TSH independent activation of the cAMP cascade resulting in thyroid growth and hormone production. TSHR mutations are found in autonomously functioning thyroid nodules (AFTN), toxic multinodular goiter (TMNG) and hyperfunctioning thyroid adenomas (HTA). TMNG encompasses a spectrum of different clinical entities, ranging from a single hyperfunctioning nodule within an enlarged thyroid, to multiple hyperfunctioning areas scattered throughout the gland. HTA are discrete encapsulated neoplasms characterized by TSH- independent autonomous growth, hypersecretion of thyroid hormones, and TSH suppression. Defects in TSHR are also a cause of thyroid neoplasms (papillary and follicular cancers). Autoantibodies against TSHR are directly responsible for the pathogenesis and hyperthyroidism of Graves disease. Antibody interaction with TSHR results in an uncontrolled receptor stimulation. Defects in TSHR are the cause of congenital hypothyroidism non-goitrous type 1 (CHNG1); also known as congenital hypothyroidism due to TSH resistance. CHNG1 is a non-autoimmune condition characterized by resistance to thyroid- stimulating hormone (TSH) leading to increased levels of plasma TSH and low levels of thyroid hormone. CHNG1 presents variable severity depending on the completeness of the defect. Most patients are euthyroid and asymptomatic, with a normal sized thyroid gland. Only a subset of patients develop hypothyroidism and present a hypoplastic thyroid gland. Defects in TSHR are the cause of familial gestational hyperthyroidism (HTFG). HTFG is a condition characterized by abnormally high levels of serum thyroid hormones occurring during early pregnancy. Defects in TSHR are the cause of hyperthyroidism non- autoimmune (HTNA). It is a condition characterized by abnormally high levels of serum thyroid hormones, thyroid hyperplasia, goiter and lack of anti-thyroid antibodies. Typical features of Graves disease such as exophthalmia, myxedema, antibodies anti-TSH receptor and lymphocytic infiltration of the thyroid gland are absent. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Cellular Component: membrane; integral to membrane; plasma membrane; receptor complex; lipid raft

Molecular Function: G-protein coupled receptor activity; signal transducer activity; protein-hormone receptor activity; thyroid-stimulating hormone receptor activity

Biological Process: regulation of locomotion; G-protein coupled receptor protein signaling pathway; inner ear receptor stereocilium organization and biogenesis; adult locomotory behavior; inner ear receptor cell development; B cell differentiation; positive regulation of cell proliferation; positive regulation of multicellular organism growth; signal transduction; G-protein signaling, adenylate cyclase activating pathway

Research Articles on TSHR

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Product Notes

The Mouse TSHR tshr (Catalog #AAA9323783) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9323783 ELISA Kit recognizes Mouse TSHR. It is sometimes possible for the material contained within the vial of "thyroid stimulating hormone receptor, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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