Mouse suppressor of Ty 4 homolog 1 (S. cerevisiae) ELISA Kit | SUPT4H1 elisa kit
Mouse Transcription elongation factor SPT4, SUPT4H1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SUPT4H1: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV- 1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences. Belongs to the SPT4 family.
Cellular Component: nucleoplasm; nucleus
Molecular Function: zinc ion binding; protein heterodimerization activity; metal ion binding
Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of RNA elongation; RNA elongation from RNA polymerase II promoter; negative regulation of RNA elongation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
Research Articles on SUPT4H1
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Product Notes
The Mouse SUPT4H1 supt4h1a (Catalog #AAA9323162) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9323162 ELISA Kit recognizes Mouse SUPT4H1. It is sometimes possible for the material contained within the vial of "suppressor of Ty 4 homolog 1 (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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