Human immunity-related GTPase family, M ELISA Kit | IRGM elisa kit
Human Immunity-related GTPase family M protein, IRGM ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010]
Uniprot Description
IRGM: Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility. Defects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19). A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Belongs to the interferon-inducible GTPase family.
Protein type: Hydrolase; Endoplasmic reticulum; EC 3.6.5.-
Chromosomal Location of Human Ortholog: 5q33.1
Cellular Component: Golgi membrane; phagocytic vesicle membrane; cell projection; phagocytic cup
Molecular Function: GTP binding; hydrolase activity
Biological Process: innate immune response; autophagy; inflammatory response
Disease: Mycobacterium Tuberculosis, Susceptibility To; Inflammatory Bowel Disease 19
Research Articles on IRGM
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Product Notes
The Human IRGM irgm (Catalog #AAA9320915) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9320915 ELISA Kit recognizes Human IRGM. It is sometimes possible for the material contained within the vial of "immunity-related GTPase family, M, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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