Mouse calcium channel, voltage-dependent, beta 4 subunit ELISA Kit | CACNB4 elisa kit
Mouse Voltage-dependent L-type calcium channel subunit beta-4, CACNB4 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
CACNB4: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB4 are the cause of susceptibility to epilepsy, idiopathic generalized type 9 (EIG9). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6). EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Defects in CACNB4 are the cause of episodic ataxia type 5 (EA5). EA5 is a disorder characterized by episodes of vertigo and ataxia that last for several hours. Interictal examination show spontaneous downbeat and gaze-evoked nystagmus, mild dysarthria and truncal ataxia. Belongs to the calcium channel beta subunit family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, calcium
Cellular Component: plasma membrane; voltage-gated calcium channel complex; synapse
Molecular Function: voltage-gated calcium channel activity; protein binding; calcium channel activity; high voltage-gated calcium channel activity; voltage-gated ion channel activity; protein kinase binding
Biological Process: spleen development; Peyer's patch development; synaptic transmission, glutamatergic; thymus development; gamma-aminobutyric acid secretion; synaptic transmission, GABAergic; T cell receptor signaling pathway; adult walking behavior; neurological system process; cellular calcium ion homeostasis; regulation of membrane potential; cAMP metabolic process; transport; calcium ion transport; action potential propagation; detection of light stimulus involved in visual perception; ion transport; muscle fiber development; gamma-aminobutyric acid signaling pathway; neuromuscular junction development; T cell differentiation
Research Articles on CACNB4
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Product Notes
The Mouse CACNB4 cacnb4 (Catalog #AAA9319757) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319757 ELISA Kit recognizes Mouse CACNB4. It is sometimes possible for the material contained within the vial of "calcium channel, voltage-dependent, beta 4 subunit, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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