Mouse hypoxia inducible factor 3, alpha subunit ELISA Kit | HIF3A elisa kit
Mouse Hypoxia-inducible factor 3-alpha, HIF3A ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
HIF3A: Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the cornea. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor; Transcription factor
Cellular Component: mitochondrion; cytoplasm; nuclear speck; nucleus
Molecular Function: protein dimerization activity; protein binding; signal transducer activity; DNA binding; transcription coactivator activity; transcription corepressor activity; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; signal transduction
Research Articles on HIF3A
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Product Notes
The Mouse HIF3A hif3a (Catalog #AAA9319185) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9319185 ELISA Kit recognizes Mouse HIF3A. It is sometimes possible for the material contained within the vial of "hypoxia inducible factor 3, alpha subunit, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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