Human lysine (K) -specific demethylase 4C ELISA Kit | KDM4C elisa kit
Human Lysine-specific demethylase 4C, KDM4C ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Uniprot Description
JMJD2C: the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis. Preferentially expressed in undifferentiated ES cells. JMJD2C, along with JMJD1A, regulate self-renewal in embryonic stem cells. Specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Two isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.-; Oxidoreductase; Demethylase
Chromosomal Location of Human Ortholog: 9p24.1
Cellular Component: nucleoplasm; nuclear chromatin
Molecular Function: enzyme binding; androgen receptor binding; zinc ion binding; dioxygenase activity; histone demethylase activity (H3-K9 specific)
Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; histone H3-K9 demethylation; transcription, DNA-dependent; positive regulation of cell proliferation
Research Articles on KDM4C
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Product Notes
The Human KDM4C kdm4c (Catalog #AAA9318943) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318943 ELISA Kit recognizes Human KDM4C. It is sometimes possible for the material contained within the vial of "lysine (K) -specific demethylase 4C, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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