Mouse sal-like 4 (Drosophila) ELISA Kit | SALL4 elisa kit

Mouse Sal-like protein 4, SALL4 ELISA Kit

Cat. Num. AAA9318930

• Gene Names: Sall4; Tex20; C78083; C78563; AA407717; AL022809; AW536104; 5730441M18Rik; C330011P20Rik
• Reactivity: Mouse
• Synonyms: sal-like 4 (Drosophila); Mouse Sal-like protein 4; SALL4 ELISA Kit; Mouse Sal-like protein 4 (SALL4) ELISA kit; DRRS; HSAL4; MGC133050; ZNF797; dJ1112F19.1; sal-like 4; SALL4 elisa kit

• Reactivity: Mouse

• Samples: Human Body Fluids And Tissue Homogenates
• Assay Type: Quantitative Sandwich
• Detection Range: 0.625ng/ml-20ng/ml
• Sensitivity: 0.1ng/ml.
• Intra-assay Precision: Intra-assay CV (%) are less than 15%
• Inter-assay Precision: Inter-assay CV (?) are less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for SALL4 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only! This kit is intended to be used for determine the level of SALL4 (hereafter termed "analyte") in undiluted original Human body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 117553631
• NCBI GeneID: 99377
• NCBI Accession #: NP_780512.2
• NCBI GenBank Nucleotide #: NM_175303.3
• UniProt Accession #: Q8BX22; Q6S7E8; Q6S7E9; Q7TST6; A2AV00
• Molecular Weight: 113,110 Da
• NCBI Official Full Name: sal-like protein 4 isoform a
• NCBI Official Synonym Full Names: sal-like 4 (Drosophila)
• NCBI Official Symbol: Sall4
• NCBI Official Synonym Symbols: Tex20; C78083; C78563; AA407717; AL022809; AW536104; 5730441M18Rik; C330011P20Rik
• NCBI Protein Information: sal-like protein 4; zinc finger protein SALL4
• UniProt Protein Name: Sal-like protein 4
• Protein Family: Sal-like protein
• UniProt Gene Name: Sall4
• UniProt Entry Name: SALL4_MOUSE

NCBI Description

This gene belongs to the spalt family of zinc finger transcription factors. In mouse, functions for this gene have been described in many embryonic developmental processes, including brain, heart, and limb development. In addition, this gene is an important pluripotency factor that is required for stem cell maintenance. Homozygous mutant mice display embryonic lethality, while conditional knock-out in embryonic germ cells results in failure to establish a robust stem cell population. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Uniprot Description

SALL4: a transcription factor and oncofetal protein expressed embryonically and in the testis. Plays a key role in maintenance and self-renewal of embryonic stem cells. Interacts with NANOG and OCT4. Ectopically expressed in acute B-cell lymphoblastic leukemia (B-ALL) and myeloid leukemia (AML), playing a role in the survival of B-ALL cells and in myeloid leukemogenesis. Aberrantly expressed in multiple carcinomas including human gastric carcinoma and hepatocellular carcinoma. Maintains the stem cell qualities of EpCAM-positive hepatocellular carcinoma cells. Expressed in primary human endometrial cancer samples but not normal or hyperplastic endometrial cells. Its expression in carcinomas positively correlates with metastatic potential and poor patient survival. Specifically binds the c-Myc promoter region in endometrial cancer cells, apparently increasing c-Myc expression. Belongs to the sal C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cancer Testis Antigen (CTA); DNA-binding; C2H2-type zinc finger protein

Cellular Component: nucleoplasm; heterochromatin; transcription factor complex; protein complex; intracellular membrane-bound organelle; cytoplasm; nucleus

Molecular Function: protein binding; DNA binding; nucleic acid binding; metal ion binding

Biological Process: neural tube development; tissue development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; in utero embryonic development; heart development; stem cell maintenance; neural tube closure; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; inner cell mass cell proliferation; embryonic limb morphogenesis