Human glycerol-3-phosphate dehydrogenase 1 (soluble) ELISA Kit | GPD1 elisa kit
Human Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic, GPD1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Uniprot Description
GPD1: Defects in GPD1 are a cause of hypertriglyceridemia, transient infantile (HTGTI). An autosomal recessive disorder characterized by onset of moderate to severe transient hypertriglyceridemia in infancy that normalizes with age. The hypertriglyceridemia is associated with hepatomegaly, moderately elevated transaminases, persistent fatty liver, and the development of hepatic fibrosis. Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
Protein type: Oxidoreductase; Lipid Metabolism - glycerophospholipid; EC 1.1.1.8
Chromosomal Location of Human Ortholog: 12q13.12
Cellular Component: glycerol-3-phosphate dehydrogenase complex; mitochondrion; cytosol
Molecular Function: glycerol-3-phosphate dehydrogenase (NAD+) activity; protein homodimerization activity; glycerol-3-phosphate dehydrogenase activity; NAD binding
Biological Process: NADH oxidation; phospholipid metabolic process; positive regulation of glycolysis; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process; glycerophosphate shuttle; cellular lipid metabolic process; glycerol-3-phosphate catabolic process; gluconeogenesis
Disease: Hypertriglyceridemia, Transient Infantile
Research Articles on GPD1
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Product Notes
The Human GPD1 gpd1 (Catalog #AAA9318416) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9318416 ELISA Kit recognizes Human GPD1. It is sometimes possible for the material contained within the vial of "glycerol-3-phosphate dehydrogenase 1 (soluble), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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