Human intraflagellar transport 57 homolog (Chlamydomonas) ELISA Kit | IFT57 elisa kit
Human Intraflagellar transport protein 57 homolog, IFT57 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
IFT57: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. Belongs to the IFT57 family.
Chromosomal Location of Human Ortholog: 3q13.13
Cellular Component: Golgi apparatus; centrosome; photoreceptor connecting cilium; cilium
Molecular Function: protein binding; DNA binding
Biological Process: caspase activation; regulation of apoptosis; smoothened signaling pathway; transcription, DNA-dependent; regulation of transcription, DNA-dependent; apoptosis; organelle organization and biogenesis; neural tube closure; intraflagellar transport; cilium biogenesis; heart looping; negative regulation of epithelial cell proliferation
Research Articles on IFT57
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Product Notes
The Human IFT57 ift57 (Catalog #AAA9317396) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9317396 ELISA Kit recognizes Human IFT57. It is sometimes possible for the material contained within the vial of "intraflagellar transport 57 homolog (Chlamydomonas), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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