Human myosin, heavy chain 10, non-muscle ELISA Kit | MYH10 elisa kit

Human Myosin-10, MYH10 ELISA Kit

Cat. Num. AAA9316086

• Gene Names: MYH10; NMMHCB; NMMHC-IIB
• Reactivity: Human
• Synonyms: myosin; heavy chain 10; non-muscle; Human Myosin-10; MYH10 ELISA Kit; Human Myosin-10 (MYH10) ELISA kit; MGC134913; MGC134914; NMMHCB; cellular myosin heavy chain; type B type B; myosin heavy chain; nonmuscle type B; heavy polypeptide 10; near to the ATP binding region; nonmuscle myosin; MYH10 elisa kit

• Reactivity: Human

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 365192532
• NCBI GeneID: 4628
• NCBI Accession #: NP_001242941.1
• NCBI GenBank Nucleotide #: NM_001256012.1
• UniProt Accession #: P35580; Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0; B2RWP9; D3DTS1; F8VTL3
• Molecular Weight: 228,999 Da
• NCBI Official Full Name: myosin-10 isoform 1
• NCBI Official Synonym Full Names: myosin, heavy chain 10, non-muscle
• NCBI Official Symbol: MYH10
• NCBI Official Synonym Symbols: NMMHCB; NMMHC-IIB
• NCBI Protein Information: myosin-10; nonmuscle myosin heavy chain IIB; nonmuscle myosin II heavy chain-B; cellular myosin heavy chain, type B; myosin heavy chain, nonmuscle type B; myosin, heavy polypeptide 10, non-muscle
• UniProt Protein Name: Myosin-10
• Protein Family: Myosin
• UniProt Gene Name: MYH10
• UniProt Synonym Gene Names: NMMHC-B; NMMHC II-b; NMMHC-IIB
• UniProt Entry Name: MYH10_HUMAN

NCBI Description

This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

MYH10: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B. Interacts with LARP6. Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: mitochondrion; myosin II complex; dendritic spine; actomyosin; cell cortex; actin cytoskeleton; growth cone; cell soma; lamellipodium; axon; cytoplasm; stress fiber; plasma membrane; spindle; midbody; neuromuscular junction; myosin complex; nucleus; cleavage furrow

Molecular Function: microfilament motor activity; calmodulin binding; actin filament binding; protein binding; ADP binding; actin binding; actin-dependent ATPase activity; ATP binding

Biological Process: adult heart development; axon guidance; exocytosis; in utero embryonic development; actin filament-based movement; metabolic process; ventricular cardiac muscle cell development; actomyosin structure organization and biogenesis; fourth ventricle development; neuron migration; cerebellar Purkinje cell layer development; cardiac myofibril assembly; third ventricle development; substrate-bound cell migration, cell extension; regulation of cell shape; cell proliferation; cytokinesis after mitosis; retina development in camera-type eye; plasma membrane repair; ephrin receptor signaling pathway; neuromuscular process controlling balance; cell adhesion; nuclear migration; lateral ventricle development