Human myosin IXB ELISA Kit | MYO9B elisa kit
Human Myosin-IXb, MYO9B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Uniprot Description
MYO9B: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. May be involved in the remodeling of the actin cytoskeleton. Binds actin with high affinity both in the absence and presence of ATP and its mechanochemical activity is inhibited by calcium ions. Also acts as a GTPase activating protein on Rho. Genetic variation in MYO9B is the cause of susceptibility to celiac disease type 4 (CELIAC4). It is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Motor; Actin-binding; Motility/polarity/chemotaxis; GAPs; GAPs, Rac/Rho
Chromosomal Location of Human Ortholog: 19p13.1
Cellular Component: ruffle; filamentous actin; filopodium tip; membrane; perinuclear region of cytoplasm; lamellipodium; cytoplasm; cell cortex; cytosol; myosin complex; actin cytoskeleton
Molecular Function: actin filament binding; calmodulin binding; microfilament motor activity; ATP-dependent protein binding; protein binding; protein homodimerization activity; zinc ion binding; ATPase activity; ADP binding; actin-dependent ATPase activity; actin binding; ATP binding
Biological Process: monocyte chemotaxis; regulation of small GTPase mediated signal transduction; ARF protein signal transduction; establishment of cell polarity; actin filament-based movement; metabolic process; small GTPase mediated signal transduction; macrophage chemotaxis
Disease: Celiac Disease, Susceptibility To, 4
Research Articles on MYO9B
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Product Notes
The Human MYO9B myo9b (Catalog #AAA9316035) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9316035 ELISA Kit recognizes Human MYO9B. It is sometimes possible for the material contained within the vial of "myosin IXB, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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