Rat G protein-activated inward rectifier potassium channel 2, KCNJ6/GIRK2 ELISA Kit | KCNJ6/GIRK2 elisa kit
Rat G protein-activated inward rectifier potassium channel 2, KCNJ6/GIRK2 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and may be involved in the regulation of insulin secretion by glucose. It associates with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]
Uniprot Description
GIRK2: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.1
Cellular Component: Golgi apparatus; voltage-gated potassium channel complex; plasma membrane
Molecular Function: protein binding; G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity
Biological Process: synaptic transmission; potassium ion import; potassium ion transport
Disease: Keppen-lubinsky Syndrome
Research Articles on KCNJ6/GIRK2
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Product Notes
The Rat KCNJ6/GIRK2 kcnj6 (Catalog #AAA9306188) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9306188 ELISA Kit recognizes Rat KCNJ6/GIRK2. It is sometimes possible for the material contained within the vial of "G protein-activated inward rectifier potassium channel 2, KCNJ6/GIRK2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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