AXIN2 blocking peptide

AXIN2 Blocking Peptide (C-term)

• Gene Names: AXIN2; AXIL; ODCRCS
• Synonyms: AXIN2; AXIN2 Blocking Peptide (C-term); Axin-2; Axin-like protein; Axil; Axis inhibition protein 2; Conductin; AXIN2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 831-843 of HUMAN AXIN2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 843

• Cellular Location: Cytoplasm.
• Tissue Location: Expressed in brain and lymphoblast.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AXIN2 blocking peptide

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta- catenin and APC by GSK3B (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 195927059
• NCBI GeneID: 8313
• NCBI Accession #: NP_004646.3
• NCBI GenBank Nucleotide #: NM_004655.3
• UniProt Accession #: Q9Y2T1; Q3MJ88; Q9H3M6; Q9UH84
• Molecular Weight: 93,558 Da
• NCBI Official Full Name: axin-2
• NCBI Official Synonym Full Names: axin 2
• NCBI Official Symbol: AXIN2
• NCBI Official Synonym Symbols: AXIL; ODCRCS
• NCBI Protein Information: axin-2
• UniProt Protein Name: Axin-2
• Protein Family: Axin
• UniProt Gene Name: AXIN2
• UniProt Synonym Gene Names: Axil
• UniProt Entry Name: AXIN2_HUMAN

NCBI Description

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]

Uniprot Description

axin 2: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q24.1

Cellular Component: beta-catenin destruction complex; cell cortex; centrosome; cytoplasm; cytoplasmic membrane-bound vesicle; cytoplasmic microtubule; cytosol; Golgi apparatus; microtubule cytoskeleton; nucleoplasm; nucleus; plasma membrane; postsynaptic density

Molecular Function: beta-catenin binding; enzyme binding; GTPase activator activity; protein binding; protein kinase binding; ubiquitin protein ligase binding

Biological Process: dorsal/ventral axis specification; intramembranous ossification; maintenance of DNA repeat elements; mRNA stabilization; negative regulation of cell proliferation; negative regulation of osteoblast differentiation; odontogenesis; positive regulation of protein amino acid phosphorylation; regulation of mismatch repair; regulation of transcription, DNA-dependent; Wnt receptor signaling pathway

Disease: Oligodontia-colorectal Cancer Syndrome