BAD (Y113) Blocking Peptide | Bad blocking peptide

Phospho-mouse BAD(Y113) Blocking Peptide

• Gene Names: Bad; Bbc2; AI325008
• Synonyms: BAD (Y113); Phospho-mouse BAD(Y113) Blocking Peptide; Bcl2-associated agonist of cell death; BAD; Bcl-2-binding component 6; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death; Bad; Bbc6; Bad blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 106-118 of MOUSE Bad
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 204

• Cellular Location: Mitochondrion outer membrane. Cytoplasm. Note: Upon phosphorylation, locates to the cytoplasm
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Bad blocking peptide

Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways.

NCBI and Uniprot Product Information

• NCBI GI #: 6671610
• NCBI GeneID: 12015
• NCBI Accession #: NP_031548.1
• NCBI GenBank Nucleotide #: NM_007522.3
• UniProt Accession #: Q61337; O35147
• Molecular Weight: 22,080 Da
• NCBI Official Full Name: bcl2-associated agonist of cell death isoform 1
• NCBI Official Synonym Full Names: BCL2-associated agonist of cell death
• NCBI Official Symbol: Bad
• NCBI Official Synonym Symbols: Bbc2; AI325008
• NCBI Protein Information: bcl2-associated agonist of cell death
• UniProt Protein Name: Bcl2-associated agonist of cell death
• Protein Family: Bcl2-associated agonist of cell death
• UniProt Gene Name: Bad
• UniProt Synonym Gene Names: Bbc6; BAD
• UniProt Entry Name: BAD_MOUSE

Uniprot Description

BAD: a proapoptotic member of the Bcl-2 family. Displaces Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad inducing the phosphorylation of Bad by Akt and p90RSK. 14-3-3 proteins bind phosphorylated Bad, inhibiting its binding to Bcl-2 and Bcl-xL. Phosphorylation by mitochondria-anchored PKA in the BH3 domain can block the dimerization of Bad and Bcl-xL.

Protein type: Apoptosis

Cellular Component: cytoplasm; cytosol; mitochondrial outer membrane; mitochondrion

Molecular Function: caspase activator activity; lipid binding; phospholipid binding; protein binding; protein heterodimerization activity; protein kinase B binding; protein kinase binding; protein phosphatase 2B binding; protein phosphatase binding

Biological Process: ADP metabolic process; apoptosis; ATP metabolic process; caspase activation; cell proliferation; cellular process regulating host cell cycle in response to virus; cytokine and chemokine mediated signaling pathway; DNA damage response, signal transduction resulting in induction of apoptosis; glucose catabolic process; glucose homeostasis; induction of apoptosis via death domain receptors; negative regulation of cytolysis; pore complex biogenesis; positive regulation of apoptosis; positive regulation of apoptosis by virus; positive regulation of B cell differentiation; positive regulation of caspase activity; positive regulation of epithelial cell proliferation; positive regulation of glucokinase activity; positive regulation of insulin secretion; positive regulation of proteolysis; positive regulation of T cell differentiation; regulation of apoptosis; regulation of caspase activity; regulation of mitochondrial membrane permeability; release of cytochrome c from mitochondria; suppression by virus of host apoptosis