DBN1 blocking peptide

DBN1 Blocking Peptide (Center)

• Gene Names: DBN1; D0S117E
• Synonyms: DBN1; DBN1 Blocking Peptide (Center); Drebrin; Developmentally-regulated brain protein; D0S117E; DBN1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 214-228 of HUMAN DBN1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 649

• Cellular Location: Cytoplasm. Cytoplasm, cell cortex. Cell junction. Note: In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC)
• Tissue Location: Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DBN1 blocking peptide

Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.

NCBI and Uniprot Product Information

• NCBI GI #: 215274247
• NCBI GeneID: 1627
• UniProt Accession #: Q16643; Q9UFZ5; A8MV58; B2RBG0
• Molecular Weight: 76,300 Da
• NCBI Official Full Name: Drebrin
• NCBI Official Synonym Full Names: drebrin 1
• NCBI Official Symbol: DBN1
• NCBI Official Synonym Symbols: D0S117E
• NCBI Protein Information: drebrin
• UniProt Protein Name: Drebrin
• Protein Family: Drebrin
• UniProt Gene Name: DBN1
• UniProt Synonym Gene Names: D0S117E
• UniProt Entry Name: DREB_HUMAN

NCBI Description

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

DBN1: a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. Expressed in brain neurons, heart, placenta, skeletal muscle, kidney and pancreas. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Actin-binding; Cytoskeletal

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: actin cytoskeleton; growth cone; plasma membrane

Molecular Function: profilin binding; protein binding

Biological Process: actin filament organization