Ptk7 blocking peptide

Mouse Ptk7 Blocking Peptide (C-term)

• Gene Names: Ptk7; chz; mPTK7/CCK4; 8430404F20Rik
• Synonyms: Ptk7; Mouse Ptk7 Blocking Peptide (C-term); Inactive tyrosine-protein kinase 7; Protein chuzhoi; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7; Ptk7 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 722-737 of HUMAN Ptk7
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1062

• Cellular Location: Membrane; Single-pass type I membrane protein. Cell junction. Note: Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells
• Tissue Location: Expressed at high levels in lung and un- pregnant uterus among adult tissues, and in the tail, limbs, somites, gut and craniofacial regions among embryonic tissues
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Ptk7 blocking peptide

Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

NCBI and Uniprot Product Information

• NCBI GI #: 81913306
• NCBI GeneID: 71461
• UniProt Accession #: Q8BKG3; Q3V422; Q6W8S9; Q8CHK5; Q8K178
• Molecular Weight: 117,532 Da
• NCBI Official Full Name: Inactive tyrosine-protein kinase 7
• NCBI Official Synonym Full Names: PTK7 protein tyrosine kinase 7
• NCBI Official Symbol: Ptk7
• NCBI Official Synonym Symbols: chz; mPTK7/CCK4; 8430404F20Rik
• NCBI Protein Information: inactive tyrosine-protein kinase 7
• UniProt Protein Name: Inactive tyrosine-protein kinase 7
• Protein Family: Inactive tyrosine-protein kinase
• UniProt Gene Name: Ptk7
• UniProt Entry Name: PTK7_MOUSE

Uniprot Description

CCK4: Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis. Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: CCK4 family; EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Cellular Component: focal adhesion; intercellular junction; membrane; plasma membrane

Molecular Function: ATP binding; kinase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: actin cytoskeleton reorganization; cell migration; convergent extension; establishment of epithelial cell polarity; establishment of planar polarity; heart development; neural tube closure; protein amino acid phosphorylation; Wnt receptor signaling pathway through beta-catenin; wound healing