FZD10 blocking peptide

FZD10 Blocking Peptide (N-term)

• Gene Names: FZD10; Fz10; FzE7; CD350; FZ-10; hFz10
• Synonyms: FZD10; FZD10 Blocking Peptide (N-term); Frizzled-10; Fz-10; hFz10; FzE7; CD350; FZD10 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 177-192 of HUMAN FZD10
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 581

• Cellular Location: Cell membrane; Multi-pass membrane protein
• Tissue Location: Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe and putamen. Weak expression detected in adult brain, heart, lung, skeletal muscle, pancreas, spleen and prostate
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FZD10 blocking peptide

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 17433091
• NCBI GeneID: 11211
• UniProt Accession #: Q9ULW2
• Molecular Weight: 65,336 Da
• NCBI Official Full Name: Frizzled-10
• NCBI Official Synonym Full Names: frizzled class receptor 10
• NCBI Official Symbol: FZD10
• NCBI Official Synonym Symbols: Fz10; FzE7; CD350; FZ-10; hFz10
• NCBI Protein Information: frizzled-10
• UniProt Protein Name: Frizzled-10
• Protein Family: Frizzled
• UniProt Gene Name: FZD10
• UniProt Synonym Gene Names: Fz-10; hFz10
• UniProt Entry Name: FZD10_HUMAN

NCBI Description

This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]

Uniprot Description

FZD10: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Belongs to the G-protein coupled receptor Fz/Smo family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, Fz/Smo family; Receptor, GPCR

Chromosomal Location of Human Ortholog: 12q24.33

Cellular Component: cell surface; cytoplasm; integral to plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; Wnt-protein binding

Biological Process: neuron differentiation; positive regulation of GTPase activity; positive regulation of JNK activity; regulation of actin cytoskeleton organization and biogenesis; Wnt receptor signaling pathway through beta-catenin