gpr126 blocking peptide
gpr126 Blocking Peptide (C-term)
Gene Names
adgrg6; gpr126; si:ch211-202p1.3
Synonyms
gpr126; gpr126 Blocking Peptide (C-term); G-protein coupled receptor 126; gpr126 blocking peptide
Specificity
The synthetic peptide sequence is selected from aa 1135-1149 of HUMAN gpr126
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
1185
Cellular Location
Cell membrane; Multi-pass membrane protein
Tissue Location
Expressed in Schwann cells of the posterior lateral line nerve and in brain.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for gpr126 blocking peptide
Orphan receptor. Required for normal differentiation of promyelinating Schwann cells and for normal myelination of axons. Signals probably through G-proteins to transiently elevate cAMP levels. Required for normal expression of the transcription factors oct6 and krox20 that are required for Schwann cells to initiate myelination.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
130,813 Da
NCBI Official Full Name
G-protein coupled receptor 126
NCBI Official Synonym Full Names
adhesion G protein-coupled receptor G6
NCBI Official Symbol
adgrg6
NCBI Official Synonym Symbols
gpr126; si:ch211-202p1.3
NCBI Protein Information
G-protein coupled receptor 126
UniProt Protein Name
G-protein coupled receptor 126
Protein Family
UniProt Gene Name
gpr126
UniProt Entry Name
GP126_DANRE
Uniprot Description
G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane. Couples to G(i)-proteins as well as G(s)-proteins (PubMed:25118328). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:19745155). Plays also a role in inner ear development (PubMed:24067352).
Research Articles on gpr126
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Product Notes
The gpr126 gpr126 (Catalog #AAA9229761) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "gpr126, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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