DLK1 blocking peptide

DLK1 Blocking Peptide (C-term)

• Gene Names: DLK1; DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1
• Synonyms: DLK1; DLK1 Blocking Peptide (C-term); Protein delta homolog 1; DLK-1; pG2; Fetal antigen 1; FA1; DLK; DLK1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 368-382 of HUMAN DLK1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 383

• Cellular Location: Membrane; Single-pass type I membrane protein
• Tissue Location: Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for DLK1 blocking peptide

May have a role in neuroendocrine differentiation.

NCBI and Uniprot Product Information

• NCBI GI #: 296439371
• NCBI GeneID: 8788
• UniProt Accession #: P80370; P15803; Q96DW5
• Molecular Weight: 33,067 Da
• NCBI Official Full Name: Protein delta homolog 1
• NCBI Official Synonym Full Names: delta like non-canonical Notch ligand 1
• NCBI Official Symbol: DLK1
• NCBI Official Synonym Symbols: DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1
• NCBI Protein Information: protein delta homolog 1
• UniProt Protein Name: Protein delta homolog 1
• Protein Family: Protein
• UniProt Gene Name: DLK1
• UniProt Synonym Gene Names: DLK; DLK-1; FA1
• UniProt Entry Name: DLK1_HUMAN

NCBI Description

This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal. [provided by RefSeq, Nov 2015]

Uniprot Description

DLK1: May have a role in neuroendocrine differentiation. Monomer. Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q32

Cellular Component: extracellular space

Biological Process: negative regulation of Notch signaling pathway