MT-ND1 blocking peptide

MT-ND1 Blocking Peptide (N-term)

• Gene Names: MT-ND1; MTND1; ND1
• Synonyms: MT-ND1; MT-ND1 Blocking Peptide (N-term); NADH-ubiquinone oxidoreductase chain 1; NADH dehydrogenase subunit 1; MTND1; NADH1; ND1; MT-ND1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 34-48 of HUMAN MT-ND1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 318

• Cellular Location: Mitochondrion inner membrane; Multi-pass membrane protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for MT-ND1 blocking peptide

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 128641
• NCBI GeneID: 4535
• UniProt Accession #: P03886; Q37523; C0JKH6
• Molecular Weight: 35,661 Da
• NCBI Official Full Name: NADH-ubiquinone oxidoreductase chain 1
• NCBI Official Synonym Full Names: mitochondrially encoded NADH dehydrogenase 1
• NCBI Official Symbol: MT-ND1
• NCBI Official Synonym Symbols: MTND1; ND1
• NCBI Protein Information: NADH dehydrogenase, subunit 1 (complex I)
• UniProt Protein Name: NADH-ubiquinone oxidoreductase chain 1
• UniProt Gene Name: MT-ND1
• UniProt Synonym Gene Names: MTND1; NADH1; ND1
• UniProt Entry Name: NU1M_HUMAN

Uniprot Description

MT-ND1: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND1 are a cause of Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resulting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON results from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ND1 are a cause of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes syndrome (MELAS). MELAS is a genetically heterogenious disorder, characterized by episodic vomiting, seizures, and recurrent cerebral insults resembling strokes and causing hemiparesis, hemianopsia, or cortical blindness. Defects in MT-ND1 may be associated with susceptibility to Alzheimer disease mitochondrial (AD-MT). Alzheimer disease is a neurodegenerative disorder characterized by progressive dementia, loss of cognitive abilities, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. The major constituent of these plaques is the neurotoxic amyloid-beta-APP 40-42 peptide (s), derived proteolytically from the transmembrane precursor protein APP by sequential secretase processing. The cytotoxic C-terminal fragments (CTFs) and the caspase-cleaved products such as C31 derived from APP, are also implicated in neuronal death. Genetic variation in MT-ND1 might contribute ot the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM). Belongs to the complex I subunit 1 family.

Protein type: Membrane protein, integral; Energy Metabolism - oxidative phosphorylation; Oxidoreductase; Mitochondrial; EC 1.6.5.3; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: -

Disease: Leber Optic Atrophy; Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-like Episodes