PKP4 blocking peptide

PKP4 Blocking Peptide (C-term)

• Gene Names: PKP4; p0071
• Synonyms: PKP4; PKP4 Blocking Peptide (C-term); Plakophilin-4; p0071; PKP4 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 1055-1068 of Human PKP4
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1192

• Cellular Location: Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell membrane; Peripheral membrane protein. Note: Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PKP4 blocking peptide

Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.

NCBI and Uniprot Product Information

• NCBI GI #: 313104155
• NCBI GeneID: 8502
• UniProt Accession #: Q99569; Q86W91
• Molecular Weight: 127,144 Da
• NCBI Official Full Name: Plakophilin-4
• NCBI Official Synonym Full Names: plakophilin 4
• NCBI Official Symbol: PKP4
• NCBI Official Synonym Symbols: p0071
• NCBI Protein Information: plakophilin-4
• UniProt Protein Name: Plakophilin-4
• Protein Family: Plakophilin
• UniProt Gene Name: PKP4
• UniProt Entry Name: PKP4_HUMAN

NCBI Description

Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

Uniprot Description

plakophilin 4: an armadillo-like protein of the beta-catenin family. A component of desmosomal plaques and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Two splice-variant isoforms have been described

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 2q24.1

Cellular Component: cell junction; cytoplasm; cytoskeleton; desmosome; intercellular junction; internal side of plasma membrane; midbody; perinuclear region of cytoplasm; plasma membrane; spindle midzone; spindle pole

Molecular Function: protein binding

Biological Process: intercellular junction assembly; positive regulation of cytokinesis; positive regulation of GTPase activity