LMAN2L blocking peptide

LMAN2L Blocking Peptide (C-term)

• Gene Names: LMAN2L; VIPL; MRT52
• Synonyms: LMAN2L; LMAN2L Blocking Peptide (C-term); VIP36-like protein; Lectin mannose-binding 2-like; LMAN2-like protein; VIPL; LMAN2L blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 348

• Cellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note: Predominantly found in the endoplasmic reticulum. Partly found in the Golgi
• Tissue Location: Expressed in numerous tissues. Highest expression in skeletal muscle and kidney, intermediate levels in heart, liver and placenta, low levels in brain, thymus, spleen, small intestine and lung.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for LMAN2L blocking peptide

May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.

NCBI and Uniprot Product Information

• NCBI GI #: 29611906
• NCBI GeneID: 81562
• UniProt Accession #: Q9H0V9; Q53GV3; Q53S67; Q63HN6; Q8NBQ6; Q9BQ14; B4DSH3; D3DXH6
• Molecular Weight: 24,712 Da
• NCBI Official Full Name: VIP36-like protein
• NCBI Official Synonym Full Names: lectin, mannose binding 2 like
• NCBI Official Symbol: LMAN2L
• NCBI Official Synonym Symbols: VIPL; MRT52
• NCBI Protein Information: VIP36-like protein
• UniProt Protein Name: VIP36-like protein
• Protein Family: VIP36-like protein
• UniProt Gene Name: LMAN2L
• UniProt Synonym Gene Names: VIPL; LMAN2-like protein
• UniProt Entry Name: LMA2L_HUMAN

NCBI Description

This gene encodes a protein belonging to the L-type lectin group of type 1 membrane proteins, which function in the mammalian early secretory pathway. These proteins contain luminal carbohydrate recognition domains, which display homology to leguminous lectins. Unlike other proteins of the group, which cycle in the early secretory pathway and are predominantly associated with post endoplasmic reticulum membranes, the protein encoded by this gene is a non-cycling resident protein of the ER, where it functions as a cargo receptor for glycoproteins. It is proposed to regulate exchange of folded proteins for transport to the Golgi and exchange of misfolded glycoproteins for transport to the ubiquitin-proteasome pathway. [provided by RefSeq, Apr 2016]

Uniprot Description

LMAN2L: May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q11.2

Cellular Component: endoplasmic reticulum membrane; Golgi apparatus; integral to membrane

Molecular Function: mannose binding

Biological Process: ER to Golgi vesicle-mediated transport; protein transport