CMKLR1 blocking peptide

CMKLR1 Blocking Peptide (C-term)

• Gene Names: CMKLR1; GPCR; CMLKR1
• Synonyms: CMKLR1; CMKLR1 Blocking Peptide (C-term); Chemokine-like receptor 1; G-protein coupled receptor ChemR23; G-protein coupled receptor DEZ; CHEMR23; DEZ; CMKLR1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 320-333 of HUMAN CMKLR1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 363

• Cellular Location: Cell membrane; Multi-pass membrane protein
• Tissue Location: Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs) High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CMKLR1 blocking peptide

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF- kappa-B. Positively regulates adipogenesis and adipocyte metabolism. Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).

NCBI and Uniprot Product Information

• NCBI GI #: 341958511
• NCBI GeneID: 780421
• UniProt Accession #: Q99788; B1PHQ8
• Molecular Weight: 41,384 Da
• NCBI Official Full Name: Chemokine-like receptor 1
• NCBI Official Symbol: CMKLR1
• NCBI Official Synonym Symbols: GPCR; CMLKR1
• NCBI Protein Information: chemokine-like receptor 1
• UniProt Protein Name: Chemokine-like receptor 1
• UniProt Gene Name: CMLKR1
• UniProt Entry Name: CML1_PIG

Uniprot Description

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism ().