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GEMIN4 blocking peptide

GEMIN4 Blocking Peptide (N-term)

Gene Names
GEMIN4; p97; HC56; HCAP1; HHRF-1
Synonyms
GEMIN4; GEMIN4 Blocking Peptide (N-term); Gem-associated protein 4; Gemin-4; Component of gems 4; p97; GEMIN4 blocking peptide
Ordering
Specificity
The synthetic peptide sequence is selected from aa 288-301 of HUMAN GEMIN4
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
1058
Cellular Location
Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, gem. Note: Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs and in the nucleolus
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for GEMIN4 blocking peptide
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
120,037 Da
NCBI Official Full Name
gem-associated protein 4
NCBI Official Synonym Full Names
gem nuclear organelle associated protein 4
NCBI Official Symbol
GEMIN4
NCBI Official Synonym Symbols
p97; HC56; HCAP1; HHRF-1
NCBI Protein Information
gem-associated protein 4
UniProt Protein Name
Gem-associated protein 4
Protein Family
UniProt Gene Name
GEMIN4
UniProt Synonym Gene Names
Gemin-4
UniProt Entry Name
GEMI4_HUMAN

NCBI Description

The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

GEMIN4: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.

Protein type: RNA-binding; Nucleolus; RNA splicing

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; nucleus; small nuclear ribonucleoprotein complex; SMN complex

Molecular Function: protein binding

Biological Process: nuclear import; spliceosomal snRNP biogenesis

Research Articles on GEMIN4

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Product Notes

The GEMIN4 gemin4 (Catalog #AAA9228869) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GEMIN4, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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