FCRL3 blocking peptide

FCRL3 Blocking Peptide (C-term)

• Gene Names: FCRL3; FCRH3; IFGP3; IRTA3; SPAP2; CD307c
• Synonyms: FCRL3; FCRL3 Blocking Peptide (C-term); Fc receptor-like protein 3; FcR-like protein 3; FcRL3; Fc receptor homolog 3; FcRH3; IFGP family protein 3; hIFGP3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD307c; FCRH3; IFGP3; IRTA3; SPAP2; FCRL3 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 709-720 of HUMAN FCRL3
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 734

• Cellular Location: Cell membrane; Single-pass type I membrane protein
• Tissue Location: Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B-cells but also expressed in NK cells (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 21314764
• NCBI GeneID: 115352
• NCBI Accession #: NP_443171.2
• NCBI GenBank Nucleotide #: NM_052939.3
• UniProt Accession #: Q96P31; Q5VXZ8; Q8N6S2; Q96LA4; Q96P27; Q96P28; Q96P29; Q96P30; A0N0M4; A8MTH7; D3DVD2
• Molecular Weight: 77,921 Da
• NCBI Official Full Name: Fc receptor-like protein 3
• NCBI Official Synonym Full Names: Fc receptor like 3
• NCBI Official Symbol: FCRL3
• NCBI Official Synonym Symbols: FCRH3; IFGP3; IRTA3; SPAP2; CD307c
• NCBI Protein Information: Fc receptor-like protein 3
• UniProt Protein Name: Fc receptor-like protein 3
• Protein Family: Fc receptor-like protein
• UniProt Gene Name: FCRL3
• UniProt Synonym Gene Names: FCRH3; IFGP3; IRTA3; SPAP2; FcR-like protein 3; FcRL3; FcRH3; hIFGP3
• UniProt Entry Name: FCRL3_HUMAN

NCBI Description

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Uniprot Description

FCRL3: Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21-q22