NR2E1 blocking peptide

NR2E1 Blocking Peptide (Center)

• Gene Names: NR2E1; TLL; TLX; XTLL
• Synonyms: NR2E1; NR2E1 Blocking Peptide (Center); Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Protein tailless homolog; Tll; hTll; TLX; NR2E1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 90-102 of HUMAN NR2E1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 385

• Cellular Location: Nucleus
• Tissue Location: Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NR2E1 blocking peptide

Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acic receptor (RAR) regulation in retinal cells.

NCBI and Uniprot Product Information

• NCBI GI #: 4507537
• NCBI GeneID: 7101
• NCBI Accession #: NP_003260.1
• NCBI GenBank Nucleotide #: NM_003269.4
• UniProt Accession #: Q9Y466; Q6ZMP8
• Molecular Weight: 46,400 Da
• NCBI Official Full Name: nuclear receptor subfamily 2 group E member 1 isoform b
• NCBI Official Synonym Full Names: nuclear receptor subfamily 2 group E member 1
• NCBI Official Symbol: NR2E1
• NCBI Official Synonym Symbols: TLL; TLX; XTLL
• NCBI Protein Information: nuclear receptor subfamily 2 group E member 1
• UniProt Protein Name: Nuclear receptor subfamily 2 group E member 1
• Protein Family: Nuclear receptor subfamily
• UniProt Gene Name: NR2E1
• UniProt Synonym Gene Names: TLX; Tll; hTll
• UniProt Entry Name: NR2E1_HUMAN

NCBI Description

The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

Uniprot Description

NR2E1: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acic receptor (RAR) regulation in retinal cells. Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 6q21

Cellular Component: nucleoplasm

Biological Process: nervous system development; transcription initiation from RNA polymerase II promoter