KTEL1 Blocking Peptide | POGLUT1 blocking peptide

KTEL1 Antibody (C-term) Blocking Peptide

• Gene Names: POGLUT1; Rumi; CLP46; MDSRP; C3orf9; KTELC1; MDS010; hCLP46; KDELCL1
• Synonyms: KTEL1; KTEL1 Antibody (C-term) Blocking Peptide; Protein O-glucosyltransferase 1; 241-; CAP10-like 46 kDa protein; hCLP46; KTEL motif-containing protein 1; Myelodysplastic syndromes relative protein; O-glucosyltransferase Rumi homolog; hRumi; Protein O-xylosyltransferase; POGLUT1; C3orf9; CLP46; KTELC1; MDSRP; POGLUT1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 392

• Cellular Location: Endoplasmic reticulum lumen
• Tissue Location: Expressed in most adult tissues at different intensities. Abundantly expressed in liver. Expressed also in brain, heart, skeletal muscle, spleen, kidney, placenta, lung and peripheral blood leukocyte. Not detectable in colon, thymus and small intestine. Expressed in the epidermis, especially in the upper parts, stratum spinosum and stratum granulosum (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for POGLUT1 blocking peptide

Dual specificity glycosyltransferase. Catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to EGF repeats, such as those found in F7, F9 and NOTCH2, on the consensus sequence C-X-S-X-P-C. Positively regulates Notch signaling without affecting Notch ligand binding.

NCBI and Uniprot Product Information

• NCBI GI #: 74730148
• NCBI GeneID: 56983
• UniProt Accession #: Q8NBL1; Q53GJ4; Q8N2T1; B2RD13
• Molecular Weight: 46,189 Da
• NCBI Official Full Name: Protein O-glucosyltransferase 1
• NCBI Official Synonym Full Names: protein O-glucosyltransferase 1
• NCBI Official Symbol: POGLUT1
• NCBI Official Synonym Symbols: Rumi; CLP46; MDSRP; C3orf9; KTELC1; MDS010; hCLP46; KDELCL1
• NCBI Protein Information: protein O-glucosyltransferase 1
• UniProt Protein Name: Protein O-glucosyltransferase 1
• Protein Family: Protein O-glucosyltransferase
• UniProt Gene Name: POGLUT1
• UniProt Synonym Gene Names: C3orf9; CLP46; KTELC1; MDSRP; hCLP46; hRumi
• UniProt Entry Name: PGLT1_HUMAN

NCBI Description

This gene encodes a protein with both O-glucosyltransferase and O-xylosyltransferase activity which localizes to the lumen of the endoplasmic reticulum. This protein has a carboxy-terminal KTEL motif which is predicted to function as an endoplasmic reticulum retention signal. This gene is an essential regulator of Notch signalling and likely plays a role in cell fate and tissue formation during development. It may also play a role in the pathogenesis of leukemia. Mutations in this gene have been associated with the autosomal dominant genodermatosis Dowling-Degos disease 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Uniprot Description

KTELC1: UDP-glucosyltransferase. Belongs to the glycosyltransferase 90 family.

Protein type: Secreted; Secreted, signal peptide; EC 2.4.2.26

Chromosomal Location of Human Ortholog: 3q13.33

Cellular Component: endoplasmic reticulum lumen

Molecular Function: glucosyltransferase activity; UDP-glucosyltransferase activity; UDP-xylosyltransferase activity

Biological Process: glycolipid metabolic process; positive regulation of Notch signaling pathway; protein amino acid O-linked glycosylation

Disease: Dowling-degos Disease 4