CYP2A13 blocking peptide

CYP2A13 Antibody (C-term) Blocking Peptide

• Gene Names: CYP2A13; CPAD; CYP2A; CYPIIA13
• Synonyms: CYP2A13; CYP2A13 Antibody (C-term) Blocking Peptide; Cytochrome P450 2A13; CYPIIA13; CYP2A13 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human CYP2A13. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 494

• Cellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
• Tissue Location: Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CYP2A13 blocking peptide

Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2'-methoxyacetophenone, N- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.

NCBI and Uniprot Product Information

• NCBI GI #: 77416854
• NCBI GeneID: 1553
• UniProt Accession #: Q16696; Q53YR8; Q6R569; Q6R570; Q9H2X2
• Molecular Weight: 56,688 Da
• NCBI Official Full Name: Cytochrome P450 2A13
• NCBI Official Synonym Full Names: cytochrome P450 family 2 subfamily A member 13
• NCBI Official Symbol: CYP2A13
• NCBI Official Synonym Symbols: CPAD; CYP2A; CYPIIA13
• NCBI Protein Information: cytochrome P450 2A13
• UniProt Protein Name: Cytochrome P450 2A13
• Protein Family: Cytochrome
• UniProt Gene Name: CYP2A13
• UniProt Entry Name: CP2AD_HUMAN

NCBI Description

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. Although its endogenous substrate has not been determined, it is known to metabolize 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a major nitrosamine specific to tobacco. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

Uniprot Description

CYP2A5: Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N- dimethylaniline, 2'-methoxyacetophenone, N- nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. Belongs to the cytochrome P450 family.

Protein type: Xenobiotic Metabolism - drug metabolism - other enzymes; Cofactor and Vitamin Metabolism - retinol; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.14.14.1; Secondary Metabolites Metabolism - caffeine; Oxidoreductase

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: endoplasmic reticulum membrane

Molecular Function: arachidonic acid epoxygenase activity; coumarin 7-hydroxylase activity; heme binding; oxygen binding; steroid hydroxylase activity

Biological Process: coumarin metabolic process; epoxygenase P450 pathway; xenobiotic metabolic process