BMX blocking peptide

BMX Antibody (Center) Blocking Peptide

• Gene Names: BMX; ETK; PSCTK2; PSCTK3
• Synonyms: BMX; BMX Antibody (Center) Blocking Peptide; Cytoplasmic tyrosine-protein kinase BMX; Bone marrow tyrosine kinase gene in chromosome X protein; Epithelial and endothelial tyrosine kinase; ETK; NTK38; BMX blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human BMX. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 675

• Cellular Location: Cytoplasm. Note: Localizes to the edges of spreading cells when complexed with BCAR1
• Tissue Location: Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for BMX blocking peptide

Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.

NCBI and Uniprot Product Information

• NCBI GI #: 1705489
• NCBI GeneID: 660
• UniProt Accession #: P51813; O60564; Q12871; A6NIH9
• Molecular Weight: 78,011 Da
• NCBI Official Full Name: Cytoplasmic tyrosine-protein kinase BMX
• NCBI Official Synonym Full Names: BMX non-receptor tyrosine kinase
• NCBI Official Symbol: BMX
• NCBI Official Synonym Symbols: ETK; PSCTK2; PSCTK3
• NCBI Protein Information: cytoplasmic tyrosine-protein kinase BMX
• UniProt Protein Name: Cytoplasmic tyrosine-protein kinase BMX
• Protein Family: Cytoplasmic tyrosine-protein kinase
• UniProt Gene Name: BMX
• UniProt Synonym Gene Names: ETK
• UniProt Entry Name: BMX_HUMAN

NCBI Description

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

Uniprot Description

Etk: a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.

Protein type: EC 2.7.10.2; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; TK group; Tec family

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: cytosol; extrinsic to internal side of plasma membrane

Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding; signal transducer activity

Biological Process: cell structure disassembly during apoptosis; innate immune response; mesoderm development; NK T cell differentiation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway