CABP1 blocking peptide

CABP1 Antibody (C-term) Blocking Peptide

• Gene Names: CABP1; CALBRAIN; HCALB_BR
• Synonyms: CABP1; CABP1 Antibody (C-term) Blocking Peptide; Calcium-binding protein 1; CaBP1; Calbrain; Caldendrin; CABP1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human CABP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 370

• Cellular Location: Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note: L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor. Note: S- CaBP1 is localized at or near the plasma membrane
• Tissue Location: Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CABP1 blocking peptide

Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 334302962
• NCBI GeneID: 9478
• UniProt Accession #: Q9NZU7; O95663; Q8N6H5; Q9NZU8
• Molecular Weight: 8,139 Da
• NCBI Official Full Name: Calcium-binding protein 1
• NCBI Official Synonym Full Names: calcium binding protein 1
• NCBI Official Symbol: CABP1
• NCBI Official Synonym Symbols: CALBRAIN; HCALB_BR
• NCBI Protein Information: calcium-binding protein 1
• UniProt Protein Name: Calcium-binding protein 1
• Protein Family: Calcium-binding protein
• UniProt Gene Name: CABP1
• UniProt Synonym Gene Names: CaBP1
• UniProt Entry Name: CABP1_HUMAN

NCBI Description

Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]

Uniprot Description

CABP1: Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D. Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Calcium-binding; Inhibitor

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: extracellular space; Golgi membrane; plasma membrane; postsynaptic density

Molecular Function: calcium-dependent protein binding; enzyme inhibitor activity; nuclear localization sequence binding; protein binding

Biological Process: negative regulation of protein import into nucleus