NUP62 blocking peptide

NUP62 Antibody (C-term E507) Blocking Peptide

• Gene Names: NUP62; p62; IBSN; SNDI
• Synonyms: NUP62; NUP62 Antibody (C-term E507) Blocking Peptide; Nuclear pore glycoprotein p62; 62 kDa nucleoporin; Nucleoporin Nup62; NUP62 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human NUP62. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 522

• Cellular Location: Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole. Note: Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NUP62 blocking peptide

Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex.

NCBI and Uniprot Product Information

• NCBI GI #: 134047855
• NCBI GeneID: 23636
• UniProt Accession #: P37198; Q503A4; Q6GTM2; Q96C43; Q9NSL1; B3KWU5
• Molecular Weight: 53,255 Da
• NCBI Official Full Name: Nuclear pore glycoprotein p62
• NCBI Official Synonym Full Names: nucleoporin 62
• NCBI Official Symbol: NUP62
• NCBI Official Synonym Symbols: p62; IBSN; SNDI
• NCBI Protein Information: nuclear pore glycoprotein p62
• UniProt Protein Name: Nuclear pore glycoprotein p62
• Protein Family: Nuclear pore glycoprotein
• UniProt Gene Name: NUP62
• UniProt Entry Name: NUP62_HUMAN

NCBI Description

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]

Uniprot Description

NUP62: Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex. Defects in NUP62 are the cause of infantile striatonigral degeneration (SNDI); also known as infantile bilateral striatal necrosis (IBSN) or familial striatal degeneration. SNDI is a neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy and mental retardation. Belongs to the nucleoporin NSP1/NUP62 family.

Protein type: Nucleoporin; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: intracellular membrane-bound organelle; nuclear envelope; nuclear membrane; nuclear pore; ribonucleoprotein complex

Molecular Function: nucleocytoplasmic transporter activity; phospholipid binding; protein binding; receptor signaling complex scaffold activity; SH2 domain binding; structural constituent of nuclear pore; thyroid hormone receptor binding; ubiquitin binding

Biological Process: cell death; cell surface receptor linked signal transduction; mitotic nuclear envelope disassembly; mRNA export from nucleus; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of programmed cell death; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of transcription, DNA-dependent; protein import into nucleus; protein sumoylation; RNA export from nucleus; RNA-mediated gene silencing; transcription, DNA-dependent; tRNA export from nucleus; viral reproduction; viral transcription

Disease: Striatonigral Degeneration, Infantile