PFTK1 Blocking Peptide | CDK14 blocking peptide

PFTK1 Antibody (N-term P82) Blocking Peptide

• Gene Names: CDK14; PFTK1; PFTAIRE1
• Synonyms: PFTK1; PFTK1 Antibody (N-term P82) Blocking Peptide; Cyclin-dependent kinase 14; Cell division protein kinase 14; Serine/threonine-protein kinase PFTAIRE-1; hPFTAIRE1; CDK14; KIAA0834; CDK14 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human PFTK1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 469

• Cellular Location: Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note: Recruited to the cell membrane by CCNY
• Tissue Location: Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for CDK14 blocking peptide

Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.

NCBI and Uniprot Product Information

• NCBI GI #: 93141297
• NCBI GeneID: 5218
• UniProt Accession #: O94921; Q75N06; Q75N22; Q8N764; Q9H3D7; Q9UDR0; A4D1E6; A6NK51; A8WFP6; B4DHG5; B4DNM2
• Molecular Weight: 47,760 Da
• NCBI Official Full Name: Cyclin-dependent kinase 14
• NCBI Official Synonym Full Names: cyclin dependent kinase 14
• NCBI Official Symbol: CDK14
• NCBI Official Synonym Symbols: PFTK1; PFTAIRE1
• NCBI Protein Information: cyclin-dependent kinase 14
• UniProt Protein Name: Cyclin-dependent kinase 14
• Protein Family: Cyclin-dependent kinase
• UniProt Gene Name: CDK14
• UniProt Synonym Gene Names: KIAA0834; PFTK1; hPFTAIRE1
• UniProt Entry Name: CDK14_HUMAN

NCBI Description

PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]

Uniprot Description

CDK14: a protein kinase of the CDK family. May play a role in meiosis as well as in neuron differentiation and/or function. Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Two alternatively spliced isoforms have been described.

Protein type: Protein kinase, CMGC; Motility/polarity/chemotaxis; Kinase, protein; Cell cycle regulation; EC 2.7.11.22; Protein kinase, Ser/Thr (non-receptor); CMGC group; CDK family; CDK/TAIRE subfamily; TAIRE subfamily

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: cytoplasm; nucleus; plasma membrane

Molecular Function: cyclin binding; cyclin-dependent protein kinase activity; protein binding

Biological Process: G2/M transition of mitotic cell cycle