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HSD17B7 blocking peptide

HSD17B7 Antibody (N-term) Blocking Peptide

Gene Names
HSD17B7; PRAP; SDR37C1
Synonyms
HSD17B7; HSD17B7 Antibody (N-term) Blocking Peptide; 3-keto-steroid reductase; 17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; Estradiol 17-beta-dehydrogenase 7; HSD17B7 blocking peptide
Ordering
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human HSD17B7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
341
Cellular Location
Cell membrane; Single-pass membrane protein.
Tissue Location
Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for HSD17B7 blocking peptide
Responsible for the reduction of the keto group on the C-3 of sterols.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
34,476 Da
NCBI Official Full Name
3-keto-steroid reductase
NCBI Official Synonym Full Names
hydroxysteroid 17-beta dehydrogenase 7
NCBI Official Symbol
HSD17B7
NCBI Official Synonym Symbols
PRAP; SDR37C1
NCBI Protein Information
3-keto-steroid reductase
UniProt Protein Name
3-keto-steroid reductase
UniProt Gene Name
HSD17B7
UniProt Synonym Gene Names
SDR37C1; 17-beta-HSD 7
UniProt Entry Name
DHB7_HUMAN

NCBI Description

HSD17B7 encodes an enzyme that functions both as a 17-beta-hydroxysteroid dehydrogenase (EC 1.1.1.62) in the biosynthesis of sex steroids and as a 3-ketosteroid reductase (EC 1.1.1.270) in the biosynthesis of cholesterol (Marijanovic et al., 2003 [PubMed 12829805]).[supplied by OMIM, May 2010]

Uniprot Description

HSD17B7: Responsible for the reduction of the keto group on the C-3 of sterols. Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; EC 1.1.1.62; Lipid Metabolism - steroid biosynthesis; Oxidoreductase; EC 1.1.1.270

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: endoplasmic reticulum membrane

Molecular Function: 3-keto sterol reductase activity

Biological Process: cholesterol biosynthetic process

Research Articles on HSD17B7

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Product Notes

The HSD17B7 hsd17b7 (Catalog #AAA9226314) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "HSD17B7, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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