NUP155 blocking peptide

NUP155 Antibody (N-term) Blocking Peptide

• Gene Names: NUP155; N155; ATFB15
• Synonyms: NUP155; NUP155 Antibody (N-term) Blocking Peptide; Nuclear pore complex protein Nup155; 155 kDa nucleoporin; Nucleoporin Nup155; KIAA0791; NUP155 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human NUP155. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1391

• Cellular Location: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Note: In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis.
• Tissue Location: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NUP155 blocking peptide

Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport.

NCBI and Uniprot Product Information

• NCBI GI #: 6093462
• NCBI GeneID: 9631
• UniProt Accession #: O75694; Q9UBE9; Q9UFL5
• Molecular Weight: 149,016 Da
• NCBI Official Full Name: Nuclear pore complex protein Nup155
• NCBI Official Synonym Full Names: nucleoporin 155
• NCBI Official Symbol: NUP155
• NCBI Official Synonym Symbols: N155; ATFB15
• NCBI Protein Information: nuclear pore complex protein Nup155
• UniProt Protein Name: Nuclear pore complex protein Nup155
• Protein Family: Nuclear pore complex protein
• UniProt Gene Name: NUP155
• UniProt Synonym Gene Names: KIAA0791
• UniProt Entry Name: NU155_HUMAN

NCBI Description

Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

Uniprot Description

NUP155: Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. Belongs to the non-repetitive/WGA-negative nucleoporin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleoporin

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: membrane; nuclear envelope

Molecular Function: protein binding; structural constituent of nuclear pore; transporter activity

Biological Process: mitotic nuclear envelope disassembly; mRNA export from nucleus; nuclear membrane organization and biogenesis; protein import into nucleus; protein sumoylation; RNA export from nucleus; RNA-mediated gene silencing; tRNA export from nucleus; viral reproduction; viral transcription

Disease: Atrial Fibrillation, Familial, 15