Western Blot (WB)
(Western Blot analysis of NLGN4X expression in transfected 293T cell line by NLGN4X polyclonal antibody. Lane 1: NLGN4X transfected lysate (89.76kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human NLGN4X Polyclonal Antibody | anti-NLGN4X antibody
NLGN4X (Neuroligin-4, X-linked, Neuroligin X, HNLX, KIAA1260, NLGN4, UNQ365/PRO701, ASPGX2, AUTSX2, MGC22376)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of NLGN4X expression in transfected 293T cell line by NLGN4X polyclonal antibody. Lane 1: NLGN4X transfected lysate (89.76kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of NLGN4X expression in transfected 293T cell line by NLGN4X polyclonal antibody. Lane 1: NLGN4X transfected lysate (89.76kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. The encoded protein interacts with discs large homolog 4 (DLG4). Mutations in this gene have been associated with autism and Asperger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Description
NLGN4X: Putative neuronal cell surface protein involved in cell- cell-interactions. Defects in NLGN4X may be the cause of susceptibility to autism X-linked type 2 (AUTSX2). AUTSX2 is a pervasive developmental disorder (PDD), prototypically characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Defects in NLGN4X may be the cause of susceptibility to X-linked Asperger syndrome 2 (ASPGX2). ASPGX2 is considered to be a form of childhood autism. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: Xp22.33
Cellular Component: postsynaptic membrane; extracellular space; cell surface; integral to plasma membrane; postsynaptic density; dendrite; integral to membrane; plasma membrane; excitatory synapse; synapse; cell junction
Molecular Function: protein binding; protein homodimerization activity; neurexin binding; cell adhesion molecule binding; receptor activity; chloride ion binding
Biological Process: regulation of synaptic transmission; neuron differentiation; organ growth; intercellular junction assembly and maintenance; metabolic process; adult behavior; synapse organization and biogenesis; cerebellum development; neuron adhesion; social behavior; learning
Disease: Asperger Syndrome, X-linked, Susceptibility To, 2; Autism, Susceptibility To, X-linked 2
Research Articles on NLGN4X
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Product Notes
The NLGN4X nlgn4x (Catalog #AAA6002576) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The NLGN4X (Neuroligin-4, X-linked, Neuroligin X, HNLX, KIAA1260, NLGN4, UNQ365/PRO701, ASPGX2, AUTSX2, MGC22376) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NLGN4X can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the NLGN4X nlgn4x for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MSRPQGLLWL PLLFTPVCVM LNSNVLLWLT ALAIKFTLID SQAQYPVVNT NYGKIRGLRT PLPNEILGPV EQYLGVPYAS PPTGERRFQP PEPPSSWTGI RNTTQFAAVC PQHLDERSLL HDMLPIWFTA NLDTLMTYVQ DQNEDCLYLN IYVPTEDDIH DQNSKKPVMV YIHGGSYMEG TGNMIDGSIL ASYGNVIVIT INYRLGILGF LSTGDQAAKG NYGLLDQIQA LRWIEENVGA FGGDPKRVTI FGSGAGASCV SLLTLSHYSE GLFQKAIIQS GTALSSWAVN YQPAKYTRIL ADKVGCNMLD TTDMVECLRN KNYKELIQQT ITPATYHIAF GPVIDGDVIP DDPQILMEQG EFLNYDIMLG VNQGEGLKFV DGIVDNEDGV TPNDFDFSVS NFVDNLYGYP EGKDTLRETI KFMYTDWADK ENPETRRKTL VALFTDHQWV APAVATADLH AQYGSPTYFY AFYHHCQSEM KPSWADSAHG DEVPYVFGIP MIGPTELFSC NFSKNDVMLS AVVMTYWTNF AKTGDPNQPV PQDTKFIHTK PNRFEEVAWS KYNPKDQLYL HIGLKPRVRD HYRATKVAFW LELVPHLHNL NEIFQYVSTT TKVPPPDMTS FPYGTRRSPA KIWPTTKRPA ITPANNPKHS KDPHKTGPED TTVLIETKRD YSTELSVTIA VGASLLFLNI LAFAALYYKK DKRRHETHRR PSPQRNTTND IAHIQNEEIM SLQMKQLEHD HECESLQAHD TLRLTCPPDY TLTLRRSPDD IPLMTPNTIT MIPNTLTGMQ PLHTFNTFSG GQNSTNLPHG HSTTRV. It is sometimes possible for the material contained within the vial of "NLGN4X, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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