Presenilin 1 (PSEN1) Blocking Peptide | PSEN1 blocking peptide

Presenilin 1 (PSEN1) Antibody (C-term) Blocking peptide

• Gene Names: PSEN1; AD3; FAD; PS1; PS-1; S182
• Synonyms: Presenilin 1 (PSEN1); Presenilin 1 (PSEN1) Antibody (C-term) Blocking peptide; Presenilin-1; PS-1; 3423-; Protein S182; Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12; PS1-CTF12; PSEN1; AD3; PS1; PSNL1; PSEN1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human PSEN1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 467

• Cellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell surface. Note: Bound to NOTCH1 also at the cell surface. Colocalizes with CDH1/2 at sites of cell-cell contact Colocalizes with CTNNB1 in the endoplasmic reticulum and the proximity of the plasma membrane. Also present in azurophil granules of neutrophils
• Tissue Location: Expressed in a wide range of tissues including various regions of the brain, liver, spleen and lymph nodes
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PSEN1 blocking peptide

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.

NCBI and Uniprot Product Information

• NCBI GI #: 1709856
• NCBI GeneID: 5663
• UniProt Accession #: P49768; O95465; Q14762; Q15719; Q15720; Q96P33; Q9UIF0; B2R6D3
• Molecular Weight: 48,997 Da
• NCBI Official Full Name: Presenilin-1
• NCBI Official Synonym Full Names: presenilin 1
• NCBI Official Symbol: PSEN1
• NCBI Official Synonym Symbols: AD3; FAD; PS1; PS-1; S182
• NCBI Protein Information: presenilin-1
• UniProt Protein Name: Presenilin-1
• Protein Family: Presenilin
• UniProt Gene Name: PSEN1
• UniProt Synonym Gene Names: AD3; PS1; PSNL1; PS-1; PS1-CTF12
• UniProt Entry Name: PSN1_HUMAN

NCBI Description

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

Uniprot Description

PSEN1: probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Regulates epithelial- cadherin function. Five alternative splice isoforms have been identified.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Cell surface; Protease; EC 3.4.23.-; Mitochondrial

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: cell junction; centrosome; endoplasmic reticulum; Golgi apparatus; integral to membrane; integral to plasma membrane; kinetochore; lipid raft; membrane; mitochondrion; nuclear membrane; nuclear outer membrane; nucleus; plasma membrane; rough endoplasmic reticulum; smooth endoplasmic reticulum

Molecular Function: beta-catenin binding; cadherin binding; calcium channel activity; endopeptidase activity; PDZ domain binding; protein binding

Biological Process: amyloid precursor protein catabolic process; cell-cell adhesion; endoplasmic reticulum calcium ion homeostasis; membrane protein ectodomain proteolysis; negative regulation of apoptosis; Notch receptor processing; positive regulation of catalytic activity; positive regulation of transcription, DNA-dependent; protein processing; regulation of phosphorylation; smooth endoplasmic reticulum calcium ion homeostasis; Wnt receptor signaling pathway through beta-catenin

Disease: Acne Inversa, Familial, 3; Alzheimer Disease 3; Cardiomyopathy, Dilated, 1u; Frontotemporal Dementia; Pick Disease Of Brain