VKORC1 blocking peptide

VKORC1 Antibody (N-term) Blocking peptide

• Gene Names: VKORC1; VKOR; MST134; MST576; VKCFD2; EDTP308
• Synonyms: VKORC1; VKORC1 Antibody (N-term) Blocking peptide; Vitamin K epoxide reductase complex subunit 1; Vitamin K1 2;3-epoxide reductase subunit 1; VKOR; VKORC1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 163

• Cellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein
• Tissue Location: Expressed at highest levels in fetal and adult liver, followed by fetal heart, kidney, and lung, adult heart, and pancreas.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for VKORC1 blocking peptide

Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Vitamin K is required for the gamma-carboxylation of various proteins, including clotting factors, and is required for normal blood coagulation, but also for normal bone development.

NCBI and Uniprot Product Information

• NCBI GI #: 13124770
• NCBI GeneID: 79001
• NCBI Accession #: NP_076869.1
• NCBI GenBank Nucleotide #: NM_024006.5
• UniProt Accession #: Q9BQB6; Q6UX90; Q7Z2R4; A6NIQ6; B2R4Z6
• Molecular Weight: 9,875 Da
• NCBI Official Full Name: vitamin K epoxide reductase complex subunit 1 isoform 1
• NCBI Official Synonym Full Names: vitamin K epoxide reductase complex subunit 1
• NCBI Official Symbol: VKORC1
• NCBI Official Synonym Symbols: VKOR; MST134; MST576; VKCFD2; EDTP308
• NCBI Protein Information: vitamin K epoxide reductase complex subunit 1
• UniProt Protein Name: Vitamin K epoxide reductase complex subunit 1
• Protein Family: Vitamin K epoxide reductase complex
• UniProt Gene Name: VKORC1
• UniProt Synonym Gene Names: VKOR
• UniProt Entry Name: VKOR1_HUMAN

NCBI Description

This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

Uniprot Description

VKORC1: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Defects in VKORC1 are a cause of combined deficiency of vitamin K-dependent clotting factors type 2 (VKCFD2). VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K. Defects in VKORC1 are a cause of coumarin resistance (CMRES). A condition characterized by partial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. Belongs to the VKOR family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Oxidoreductase; Membrane protein, multi-pass; EC 1.1.4.1

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: endoplasmic reticulum membrane

Molecular Function: vitamin-K-epoxide reductase (warfarin-sensitive) activity

Biological Process: blood coagulation; drug metabolic process; peptidyl-glutamic acid carboxylation; vitamin K metabolic process

Disease: Coumarin Resistance; Vitamin K-dependent Clotting Factors, Combined Deficiency Of, 2