FDPS blocking peptide

FDPS Antibody (Center) Blocking Peptide

• Gene Names: FDPS; FPS; FPPS; POROK9
• Synonyms: FDPS; FDPS Antibody (Center) Blocking Peptide; Farnesyl pyrophosphate synthase; FPP synthase; FPS; (2E;6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Geranyltranstransferase; KIAA1293; FDPS blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human FDPS. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 419

• Cellular Location: Cytoplasm.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for FDPS blocking peptide

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

NCBI and Uniprot Product Information

• NCBI GI #: 215274250
• NCBI GeneID: 2224
• UniProt Accession #: P14324; Q96G29; D3DV91; E9PCI9
• Molecular Weight: 40,532 Da
• NCBI Official Full Name: Farnesyl pyrophosphate synthase
• NCBI Official Synonym Full Names: farnesyl diphosphate synthase
• NCBI Official Symbol: FDPS
• NCBI Official Synonym Symbols: FPS; FPPS; POROK9
• NCBI Protein Information: farnesyl pyrophosphate synthase
• UniProt Protein Name: Farnesyl pyrophosphate synthase
• Protein Family: Farnesyl pyrophosphate synthase
• UniProt Gene Name: FDPS
• UniProt Synonym Gene Names: FPS; KIAA1293; FPP synthase; FPS
• UniProt Entry Name: FPPS_HUMAN

NCBI Description

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

Uniprot Description

FDPS: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. Belongs to the FPP/GGPP synthase family.

Protein type: Motility/polarity/chemotaxis; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; EC 2.5.1.1; EC 2.5.1.10; Transferase

Chromosomal Location of Human Ortholog: 1q22

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: dimethylallyltranstransferase activity; geranyltranstransferase activity

Biological Process: cholesterol biosynthetic process; farnesyl diphosphate biosynthetic process