NCAPH blocking peptide

NCAPH Antibody (Center) Blocking Peptide

• Gene Names: NCAPH; BRRN1; CAP-H
• Synonyms: NCAPH; NCAPH Antibody (Center) Blocking Peptide; Condensin complex subunit 2; Barren homolog protein 1; Chromosome-associated protein H; hCAP-H; Non-SMC condensin I complex subunit H; XCAP-H homolog; BRRN; BRRN1; CAPH; KIAA0074; NCAPH blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 741

• Cellular Location: Nucleus. Cytoplasm. Chromosome. Note: In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase
• Tissue Location: Widely expressed at low level. Expressed in proliferating cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NCAPH blocking peptide

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

NCBI and Uniprot Product Information

• NCBI GI #: 116241306
• NCBI GeneID: 23397
• UniProt Accession #: Q15003; Q8TB87; B4E189
• Molecular Weight: 67,495 Da
• NCBI Official Full Name: Condensin complex subunit 2
• NCBI Official Synonym Full Names: non-SMC condensin I complex subunit H
• NCBI Official Symbol: NCAPH
• NCBI Official Synonym Symbols: BRRN1; CAP-H
• NCBI Protein Information: condensin complex subunit 2
• UniProt Protein Name: Condensin complex subunit 2
• Protein Family: Condensin complex
• UniProt Gene Name: NCAPH
• UniProt Synonym Gene Names: BRRN; BRRN1; CAPH; KIAA0074; hCAP-H
• UniProt Entry Name: CND2_HUMAN

NCBI Description

This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]

Uniprot Description

NCAPH: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. Belongs to the CND2 (condensin subunit 2) family.

Protein type: Cell cycle regulation

Chromosomal Location of Human Ortholog: 2q11.2

Cellular Component: condensin complex; cytosol; membrane

Molecular Function: protein binding

Biological Process: mitotic chromosome condensation