GNPTG blocking peptide

GNPTG Antibody (C-term) Blocking Peptide

• Gene Names: GNPTG; RJD9; GNPTAG; LP2537; C16orf27
• Synonyms: GNPTG; GNPTG Antibody (C-term) Blocking Peptide; N-acetylglucosamine-1-phosphotransferase subunit gamma; GlcNAc-1-phosphotransferase subunit gamma; UDP-N-acetylglucosamine-1-phosphotransferase subunit gamma; C16orf27; GNPTAG; GNPTG blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 305

• Cellular Location: Secreted. Golgi apparatus
• Tissue Location: Widely expressed.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for GNPTG blocking peptide

Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors.

NCBI and Uniprot Product Information

• NCBI GI #: 71152085
• NCBI GeneID: 84572
• UniProt Accession #: Q9UJJ9; Q6XYD7; Q96L13; B2R556
• Molecular Weight: 33,974 Da
• NCBI Official Full Name: N-acetylglucosamine-1-phosphotransferase subunit gamma
• NCBI Official Synonym Full Names: N-acetylglucosamine-1-phosphate transferase gamma subunit
• NCBI Official Symbol: GNPTG
• NCBI Official Synonym Symbols: RJD9; GNPTAG; LP2537; C16orf27
• NCBI Protein Information: N-acetylglucosamine-1-phosphotransferase subunit gamma
• UniProt Protein Name: N-acetylglucosamine-1-phosphotransferase subunit gamma
• Protein Family: N-acetylglucosamine-1-phosphotransferase
• UniProt Gene Name: GNPTG
• UniProt Synonym Gene Names: C16orf27; GNPTAG
• UniProt Entry Name: GNPTG_HUMAN

NCBI Description

This gene encodes the gamma sunbunit of the N-acetylglucosamine-1-phosphotransferase complex. This hexameric complex, composed of alpha, beta and gamma subunits, catalyzes the first step in synthesis of a mannose 6-phosphate lysosomal recognition marker. This enzyme complex is necessary for targeting of lysosomal hydrolases to the lysosome. Mutations in the gene encoding the gamma subunit have been associated with mucolipidosis IIIC, also known as mucolipidosis III gamma.[provided by RefSeq, Feb 2010]

Uniprot Description

GNPTG: the gamma subunit of N-acetylglucosamine-1-phosphotransferase. May recognize the substrate of GlcNAc-1-phosphotransferase but also lysosomal proteins with mannose-6-phosphate residues. Defects in GNPTG cause a variant of pseudo-Hurler polydystrophy, an autosomal recessive disease of lysosomal hydrolase trafficking.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: Golgi apparatus

Molecular Function: protein homodimerization activity

Biological Process: carbohydrate phosphorylation

Disease: Mucolipidosis Iii Gamma